4’-DMA-7,8-DHF is a nootropic derived from 7,8-Dihydroxyflavone, formulated to enhance cognitive function, improve memory retention, support neuroprotection, and offer potential antidepressant effects, making it a versatile compound for brain health.
Time to notice full effects: 1-2 Weeks (With Acute Effects)
What Are 4’-DMA-7,8-DHF Capsules?
4'-Dimethylamino 7,8 Dihydroxyflavone (4’-DMA-7,8-DHF) is a nootropic compound derivative of the naturally occurring flavone 7,8 Dihydroxyflavone (7,8 DHF). 4’-DMA-7,8-DHF differs from 7,8-DHF by the addition of a dimethylamino group off the 4 position on the flavone base structure. A dimethyl amino group consists of a nitrogen atom with two methyl groups.
Chemical Properties of 4’-DMA-7,8-DHF
4’-DMA-7,8-DHF is slightly water soluble and also slightly lipid soluble, this is derived from the cLogP value of 4’-DMA-7,8-DHF, which is 2.28. This means that 4’-DMA-7,8-DHF can readily transition from the aqueous phase to the lipid phase. Below is an in depth description of 4’-DMA-7,8-DHF chemical properties:
Molecular formula: C17H15NO4
Molecular weight: 297.31 g/mol
Number of Heavy Atoms: 22
Number of aromatic heavy atoms: 16
Fraction of SP3 Carbon: 0.12
Number of rotatable bonds: 2
Number of hydrogen bond acceptors: 4
Number of hydrogen bond donors: 2
Molar refractivity: 86.17
Topological polar surface area: 73.91 square Angstrom
CAS: 1205548-04-4
IUPAC: 2-[4'-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one
What Is The Difference Between 7,8 DHF and 4’-DMA-7,8-DHF?
4’-DMA-7,8-DHF shares the same chemical structure as 7,8 DHF, but with the addition of a dimethylamino group at the 4 position off the flavone base structure. The dimethylamino significantly changes a few key chemical properties of 7,8 DHF, of particular note are:
Number of heavy atoms (4’-DMA-7,8-DHF gains 3 heavy atoms)
7,8 DHF: 19
4’-DMA-7,8-DHF: 22
Fraction of SP3 Carbon (difference of 0.12)
7,8 DHF: 0.00
4’-DMA-7,8-DHF: 0.12
Rotatable bond (4’-DMA-7,8-DHF gains 1 additional rotatable bond)
7,8 DHF: 1 rotatable bond
4’-DMA-7,8-DHF: 2 rotatable bonds
Molar refractivity (difference of 14.2)
7,8 DHF: 71.97
4’-DMA-7,8-DHF: 86.17
The rest of the chemical properties stay largely unchanged, for example, 7,8 DHF and 4’-DMA-7,8-DHF have the same amount of aromatic heavy atoms, hydrogen bond donors and hydrogen bond acceptors. Their cLogP’s are also very similar (7,8 DHF: 2.35 vs 4’-DMA-7,8-DHF: 2.28), thereby indicating that 7,8 DHF and 4’-DMA-7,8-DHF are going to largely have the same water and lipid soluble properties. Their topological polar surface area is also very similar, and only differs by 3.24 square Angstrom (7,8 DHF: 70.67 vs 4’-DMA-7,8-DHF: 73.91).
